My research includes the study of mechanisms of organic reaction involving cyclic ethers and imines or metal ion catalysis. Knowledge gained here can improve useful reactions. I also work on structure determination.

Our recent study of the cuprous halide-catalyzed fragmentation of various propargylic amines revealed a new type of copper catalysis, involving intramolecular hydrogen transport by means of CuH. A study of trichothecin epoxides (toxic fungal metabolites) reactions created a practical method of detoxifying vomitoxin-infested grain. A current study is in progress on the reaction of epoxides with hypohalites. Collaboration with faculty in other departments provided exciting opportunities to participate in studies on the mechanism of direct carcinogenesis by aflatoxins, as well as to elucidate the original contents of some ancient Greek vases.