My research activities have been concerned with the design and synthesis of metal-based radiotracers for biomedical applications. More recently, I have become interested in the process of in vivo complexation, where an administered chelating agent is used to rid the body of an unwanted metal (chelation therapy). These pursuits are multi-disciplinary and combine organic, inorganic, analytical and radiochemical skills with the development of appropriate in vitro and in vivo protocols. A high priority of my research efforts since coming to Missouri (9/00) is the exploration and extension of the utility of radionuclides produced at MURR for radiotherapeutic applications. Central to this pursuit is the design and synthesis of novel chelating agents for radiolanthanides. These novel agents will combine the natural strength of nitrogen and oxygen donor ligands with the ease of complexation needed for in vivo and in vitro stability.