Neurotransmitter Sensors  |  Cooperativity in Molecular Recognition  |  Lipid Sensors

Neurotransmitter Sensors

We have been interested in a class of coumarin aldehydes which act by 'binding' to amine guests through the formation of imines with an activated aldehyde. These compounds are drug-like molecules designed to enter the cell and fluoresce in the presence of the amine of interest. We have made sensors for neurotransmitters such as dopamine and continue these efforts toward sensors for glutamate and other targets.